Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

V. Castell, José; J. Gómez-Lechón, Maria; David, Martina; Andus, Tilo; Geiger, Thomas; Trullenque, Ramón; Fabra, Ricardo; C. Heinrich, Peter

doi:10.1016/0014-5793(89)80476-4

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Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

Shared by NobleBlocks on Jan 2, 1989 • 12:00 AM UTC

Authors:

José V. Castell

Maria J. Gómez-Lechón

Martina David

Abstract

The three monokines interleukin‐1β (IL‐1β), tumor necrosis factor α (TNFα), and interleukin‐6 (IL‐6) modulate acute phase plasma protein synthesis in adult human hepatocytes. Only IL‐6 stimulates the synthesis of the full spectrum of acute phase proteins as seen in inflammatory states in humans, i.e...

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