Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model: molecular mechanisms of delayed angiogenesis in diabetes.

Y, Taniyama; R, Morishita; K, Hiraoka; M, Aoki; H, Nakagami; K, Yamasaki; K, Matsumoto; T, Nakamura; Y, Kaneda; T, Ogihara

doi:10.1161/hc4401.098470

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Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model: molecular mechanisms of delayed angiogenesis in diabetes.

Published in Circulation • Nov 1, 2001

Authors:

Taniyama Y

Morishita R

Hiraoka K

Abstract

<h4>Background</h4>Because no study has documented the angiogenic properties of hepatocyte growth factor (HGF) in a diabetes model, we examined the feasibility of gene therapy using HGF to treat peripheral arterial disease in diabetes.<h4>Methods and results</h4>Because intramuscular injection of lu...

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