Assessment of an extended dataset of in vitro human dermal absorption studies on pesticides to determine default values, opportunities for read-across and influence of dilution on absorption.

M, Aggarwal; P, Fisher; A, Hüser; FM, Kluxen; R, Parr-Dobrzanski; M, Soufi; C, Strupp; C, Wiemann; R, Billington

doi:10.1016/j.yrtph.2015.02.017

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Assessment of an extended dataset of in vitro human dermal absorption studies on pesticides to determine default values, opportunities for read-across and influence of dilution on absorption.

Shared by NobleBlocks on Mar 9, 2015 • 12:00 AM UTC

Authors:

Aggarwal M

Fisher P

Hüser A

Abstract

Dermal absorption is a key parameter in non-dietary human safety assessments for agrochemicals. Conservative default values and other criteria in the EFSA guidance have substantially increased generation of product-specific in vitro data and in some cases, in vivo data. Therefore, data from 190 GLP-...

Subject

Pesticides

In vitro

risk assessment

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