Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans.

H, Takahashi; GR, Wilkinson; EA, Nutescu; T, Morita; MD, Ritchie; MG, Scordo; V, Pengo; M, Barban; R, Padrini; I, Ieiri; K, Otsubo; T, Kashima; S, Kimura; S, Kijima; H, Echizen

doi:10.1097/01.fpc.0000184955.08453.a8

Public

Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans.

Shared by NobleBlocks on Feb 1, 2006 • 12:00 AM UTC

Authors:

Takahashi H

Wilkinson GR

Nutescu EA

Abstract

<h4>Objective</h4>To investigate pharmacokinetic and pharmacodynamic factors associated with population differences in warfarin doses needed to achieve anticoagulation, in particular the possible involvement of genetic variability in vitamin K epoxide reductase (VKOR) and CYP2C9.<h4>Methods</h4>Warf...

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