A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate.

N, Ruperto; KJ, Murray; V, Gerloni; N, Wulffraat; Oliveira SK, de; F, Falcini; P, Dolezalova; M, Alessio; R, Burgos-Vargas; F, Corona; R, Vesely; H, Foster; J, Davidson; F, Zulian; L, Asplin; E, Baildam; JG, Consuegra; H, Ozdogan; R, Saurenmann; R, Joos; A, Pistorio; P, Woo; A, Martini

doi:10.1002/art.20288

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A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate.

Shared by NobleBlocks on Jul 1, 2004 • 12:00 AM UTC

Authors:

Ruperto N

Murray KJ

Gerloni V

Abstract

<h4>Objective</h4>To compare the safety and efficacy of parenteral methotrexate (MTX) at an intermediate dosage (15 mg/m(2)/week) versus a higher dosage (30 mg/m(2)/week) in patients with polyarticular-course juvenile idiopathic arthritis (JIA) who failed to improve while receiving standard dosages ...

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