Concise and efficient synthesis of 4-fluoro-1H-pyrrolo[2,3-b]pyridine.

C, Thibault; A, L'Heureux; RS, Bhide; R, Ruel

doi:10.1021/ol036030z

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Concise and efficient synthesis of 4-fluoro-1H-pyrrolo[2,3-b]pyridine.

Shared by NobleBlocks on Dec 1, 2003 • 12:00 AM UTC

Authors:

Thibault C

L'Heureux A

Bhide RS

Abstract

Two routes describing the preparation of 4-fluoro-1H-pyrrolo[2,3-b]pyridine (4a) from 1H-pyrrolo[2,3-b]pyridine N-oxide (1) are presented. Regioselective fluorination was achieved using either the Balz-Schiemann reaction or lithium-halogen exchange. [reaction: see text]

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