Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells.

N, Egawa; N, Koshikawa; T, Tomari; K, Nabeshima; T, Isobe; M, Seiki

doi:10.1074/jbc.m606993200

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Membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) cleaves and releases a 22-kDa extracellular matrix metalloproteinase inducer (EMMPRIN) fragment from tumor cells.

Shared by NobleBlocks on Oct 18, 2006 • 12:00 AM UTC

Authors:

Egawa N

Koshikawa N

Tomari T

Abstract

Proteolytic shedding is an important step in the functional down-regulation and turnover of most membrane proteins at the cell surface. Extracellular matrix metalloproteinase inducer (EMMPRIN) is a multifunctional glycoprotein that has two Ig-like domains in its extracellular portion and functions i...

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