Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.

Udagawa, N; Takahashi, N; Akatsu, T; Tanaka, H; Sasaki, T; Nishihara, T; Koga, T; J Martin, T; Suda, T

doi:10.1073/pnas.87.18.7260

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Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.

Shared by NobleBlocks on Sep 1, 1990 • 12:00 AM UTC

Authors:

N Udagawa

N Takahashi

T Akatsu

Abstract

We previously reported that osteoclast-like cells were formed in cocultures of a mouse marrow-derived stromal cell line (ST2) with mouse spleen cells in the presence of 1 alpha, 25-dihydroxyvitamin D3 and dexamethasone. In this study, we developed a new coculture system to determine the origin of os...

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