HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases.

C, Michiels; E, Minet; G, Michel; D, Mottet; JP, Piret; M, Raes

doi:10.1080/15216540252774766

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HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: role of MAP kinases.

Shared by NobleBlocks on Jul 1, 2001 • 12:00 AM UTC

Authors:

Michiels C

Minet E

Michel G

Abstract

HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the adaptative response of cells to hypoxia. AP-1 activation by hypoxia has also been demonstrated in several...

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