Pitavastatin prevents NMDA-induced retinal ganglion cell death by suppressing leukocyte recruitment.

T, Nakazawa; H, Takahashi; K, Nishijima; M, Shimura; N, Fuse; M, Tamai; A, Hafezi-Moghadam; K, Nishida

doi:10.1111/j.1471-4159.2006.04274.x

Public

Pitavastatin prevents NMDA-induced retinal ganglion cell death by suppressing leukocyte recruitment.

Shared by NobleBlocks on Feb 1, 2007 • 12:00 AM UTC

Authors:

Nakazawa T

Takahashi H

Nishijima K

Abstract

Excitotoxicity is a major cause of retinal ganglion cell (RGC) death during ischemic diseases such as vessel occlusion and diabetic retinopathy. However, the underlying mechanisms are not well understood. Statins, inhibitors of the HMG-CoA reductase, have neuroprotective effects in addition to their...

Discussions