Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors

Gasparre, Giuseppe; Maria Porcelli, Anna; Bonora, Elena; Fiammetta Pennisi, Lucia; Toller, Matteo; Iommarini, Luisa; Ghelli, Anna; Moretti, Massimo; M. Betts, Christine; Nicola Martinelli, Giuseppe; Rinaldi Ceroni, Alberto; Curcio, Francesco; Carelli, Valerio; Rugolo, Michela; Tallini, Giovanni; Romeo, Giovanni

doi:10.1073/pnas.0703056104

Public

Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors

Shared by NobleBlocks on May 22, 2007 • 12:00 AM UTC

Authors:

Giuseppe Gasparre

Anna Maria Porcelli

Elena Bonora

Abstract

Oncocytic tumors are a distinctive class of proliferative lesions composed of cells with a striking degree of mitochondrial hyperplasia that are particularly frequent in the thyroid gland. To understand whether specific mitochondrial DNA (mtDNA) mutations are associated with the accumulation of mito...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!