A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters.

B, Hsiang; Y, Zhu; Z, Wang; Y, Wu; V, Sasseville; WP, Yang; TG, Kirchgessner

doi:10.1074/jbc.274.52.37161

Public

A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters.

Shared by NobleBlocks on Dec 1, 1999 • 12:00 AM UTC

Authors:

Hsiang B

Zhu Y

Wang Z

Abstract

A novel human organic transporter, OATP2, has been identified that transports taurocholic acid, the adrenal androgen dehydroepiandrosterone sulfate, and thyroid hormone, as well as the hydroxymethylglutaryl-CoA reductase inhibitor, pravastatin. OATP2 is expressed exclusively in liver in contrast to ...

Discussions