Recurrent BRAF mutations in Langerhans cell histiocytosis

Badalian-Very, Gayane; Vergilio, Jo-Anne; A. Degar, Barbara; E. MacConaill, Laura; Brandner, Barbara; L. Calicchio, Monica; C. Kuo, Frank; H. Ligon, Azra; E. Stevenson, Kristen; M. Kehoe, Sarah; A. Garraway, Levi; C. Hahn, William; Meyerson, Matthew; D. Fleming, Mark; J. Rollins, Barrett

doi:10.1182/blood-2010-04-279083

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Recurrent BRAF mutations in Langerhans cell histiocytosis

Shared by NobleBlocks on Sep 16, 2010 • 12:00 AM UTC

Authors:

Gayane Badalian-Very

Jo-Anne Vergilio

Barbara A. Degar

Abstract

Abstract Langerhans cell histiocytosis (LCH) has a broad spectrum of clinical behaviors; some cases are self-limited, whereas others involve multiple organs and cause significant mortality. Although Langerhans cells in LCH are clonal, their benign morphology and their lack (to date) of reported recu...

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