Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury.

AJ, Coito; R, Buelow; XD, Shen; F, Amersi; C, Moore; HD, Volk; RW, Busuttil; JW, Kupiec-Weglinski

doi:10.1097/00007890-200207150-00017

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Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury.

Shared by NobleBlocks on Jul 1, 2002 • 12:00 AM UTC

Authors:

Coito AJ

Buelow R

Shen XD

Abstract

<h4>Background</h4>Ischemia/reperfusion (I/R) injury is a critical factor in the dysfunction of steatotic orthotopic liver transplants. Heme oxygenase-1 (HO-1), a cytoprotective protein, may be important in ameliorating hepatic I/R injury.<h4>Methods</h4>We used adenovirus (Ad)-based HO-1 gene trans...

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