Rare variants in SOS2 and LZTR1 are associated with Noonan syndrome.

<h4>Background</h4>Noonan syndrome is an autosomal dominant, multisystemic disorder caused by dysregulation of the RAS/mitogen activated protein kinase (MAPK) pathway. Heterozygous, pathogenic variants in 11 known genes account for approximately 80% of cases. The identification of novel genes associ... View More