Intra-lesional injections of recombinant human epidermal growth factor promote granulation and healing in advanced diabetic foot ulcers: multicenter, randomised, placebo-controlled, double-blind study.

JI, Fernández-Montequín; CM, Valenzuela-Silva; OG, Díaz; W, Savigne; N, Sancho-Soutelo; F, Rivero-Fernández; P, Sánchez-Penton; L, Morejón-Vega; H, Artaza-Sanz; A, García-Herrera; C, González-Benavides; CM, Hernández-Cañete; A, Vázquez-Proenza; J, Berlanga-Acosta; PA, López-Saura

doi:10.1111/j.1742-481x.2009.00641.x

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Intra-lesional injections of recombinant human epidermal growth factor promote granulation and healing in advanced diabetic foot ulcers: multicenter, randomised, placebo-controlled, double-blind study.

Shared by NobleBlocks on Dec 1, 2009 • 12:00 AM UTC

Authors:

Fernández-Montequín JI

Valenzuela-Silva CM

Díaz OG

Abstract

A multicenter, double-blind, placebo-controlled trial was carried out to evaluate the intra-lesional infiltration of recombinant epidermal growth factor (EGF) in Wagner's grade 3 or 4 diabetic foot ulcers (DFUs). Subjects (149) were randomised to receive EGF (75 or 25 microg) or placebo, three times...

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