Unnecessary antiretroviral treatment switches and accumulation of HIV resistance mutations; two arguments for viral load monitoring in Africa.

KC, Sigaloff; RL, Hamers; CL, Wallis; C, Kityo; M, Siwale; P, Ive; ME, Botes; K, Mandaliya; M, Wellington; A, Osibogun; WS, Stevens; Vugt M, van; Wit TF, de

doi:10.1097/qai.0b013e318227fc34

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Unnecessary antiretroviral treatment switches and accumulation of HIV resistance mutations; two arguments for viral load monitoring in Africa.

Shared by NobleBlocks on Sep 1, 2011 • 12:00 AM UTC

Authors:

Sigaloff KC

Hamers RL

Wallis CL

Abstract

<h4>Objectives</h4>This study aimed to investigate the consequences of using clinicoimmunological criteria to detect antiretroviral treatment (ART) failure and guide regimen switches in HIV-infected adults in sub-Saharan Africa. Frequencies of unnecessary switches, patterns of HIV drug resistance, a...

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