A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA.

G, Hutvágner; J, McLachlan; AE, Pasquinelli; E, Bálint; T, Tuschl; PD, Zamore

doi:10.1126/science.1062961

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A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA.

Shared by NobleBlocks on Jul 12, 2001 • 12:00 AM UTC

Authors:

Hutvágner G

McLachlan J

Pasquinelli AE

Abstract

The 21-nucleotide small temporal RNA (stRNA) let-7 regulates developmental timing in Caenorhabditis elegans and probably in other bilateral animals. We present in vivo and in vitro evidence that in Drosophila melanogaster a developmentally regulated precursor RNA is cleaved by an RNA interference-li...

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