Mycophenolate acid inhibits endothelial NAD(P)H oxidase activity and superoxide formation by a Rac1-dependent mechanism.

F, Krötz; M, Keller; S, Derflinger; H, Schmid; T, Gloe; F, Bassermann; J, Duyster; CD, Cohen; C, Schuhmann; V, Klauss; U, Pohl; HU, Stempfle; HY, Sohn

doi:10.1161/01.hyp.0000251162.14782.d4

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Mycophenolate acid inhibits endothelial NAD(P)H oxidase activity and superoxide formation by a Rac1-dependent mechanism.

Shared by NobleBlocks on Nov 13, 2006 • 12:00 AM UTC

Authors:

Krötz F

Keller M

Derflinger S

Abstract

Endothelial dysfunction precedes hypertension and atherosclerosis and predicts cardiac allograft vasculopathy and death in heart transplant recipients. Endothelial overproduction of reactive oxygen species, such as superoxide anions produced by NAD(P)H oxidase, induces endothelial dysfunction. Becau...

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