Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

Lammich, Sven; Kojro, Elzbieta; Postina, Rolf; Gilbert, Sandra; Pfeiffer, Roland; Jasionowski, Marek; Haass, Christian; Fahrenholz, Falk

doi:10.1073/pnas.96.7.3922

Public

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

Shared by NobleBlocks on Mar 28, 1999 • 12:00 AM UTC

Authors:

Sven Lammich

Elzbieta Kojro

Rolf Postina

Abstract

Amyloid β peptide (Aβ), the principal proteinaceous component of amyloid plaques in brains of Alzheimer’s disease patients, is derived by proteolytic cleavage of the amyloid precursor protein (APP). Proteolytic cleavage of APP by a putative α-secretase within the Aβ sequence precludes the formation ...

Discussions