The role of sex and weight on rituximab clearance and serum elimination half-life in elderly patients with DLBCL.

C, Müller; N, Murawski; MH, Wiesen; G, Held; V, Poeschel; S, Zeynalova; M, Wenger; C, Nickenig; N, Peter; E, Lengfelder; B, Metzner; T, Rixecker; C, Zwick; M, Pfreundschuh; M, Reiser

doi:10.1182/blood-2011-09-380949

Public

The role of sex and weight on rituximab clearance and serum elimination half-life in elderly patients with DLBCL.

Shared by NobleBlocks on Feb 15, 2012 • 12:00 AM UTC

Authors:

Müller C

Murawski N

Wiesen MH

Abstract

Pharmacokinetics of 8 doses of rituximab (375 mg/m(2)) given in combination with 2-week cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone/prednisolone (CHOP-14) was determined by ELISA in 20 elderly patients with diffuse large B-cell lymphoma (DLBCL) 10 minutes before and after each...

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