Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells.

L, Bordone; MC, Motta; F, Picard; A, Robinson; US, Jhala; J, Apfeld; T, McDonagh; M, Lemieux; M, McBurney; A, Szilvasi; EJ, Easlon; SJ, Lin; L, Guarente

doi:10.1371/journal.pbio.0040031

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Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells.

Published in PLoS biology • Dec 27, 2005

Authors:

Bordone L

Motta MC

Picard F

Abstract

Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower organisms. In Caenorhabditis elegans a possible genetic link between Sir2 and the insulin/IGF-1 pathway has been reported. Here we investigate such a link in mammals. We show that Sirt1 positively regulates insulin secret...

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