Poly(ADP-ribose) (PAR) polymer is a death signal

A. Andrabi, Shaida; Soo Kim, No; Yu, Seong-Woon; Wang, Hongmin; W. Koh, David; Sasaki, Masayuki; A. Klaus, Judith; Otsuka, Takashi; Zhang, Zhizheng; C. Koehler, Raymond; D. Hurn, Patricia; G. Poirier, Guy; L. Dawson, Valina; M. Dawson, Ted

doi:10.1073/pnas.0606526103

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Poly(ADP-ribose) (PAR) polymer is a death signal

Shared by NobleBlocks on Nov 28, 2006 • 12:00 AM UTC

Authors:

Shaida A. Andrabi

No Soo Kim

Seong-Woon Yu

Abstract

Excessive activation of the nuclear enzyme, poly(ADP-ribose) polymerase-1 (PARP-1) plays a prominent role in various of models of cellular injury. Here, we identify poly(ADP-ribose) (PAR) polymer, a product of PARP-1 activity, as a previously uncharacterized cell death signal. PAR polymer is directl...

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