Large-scale DNA microarray analysis of atopic skin lesions shows overexpression of an epidermal differentiation gene cluster in the alternative pathway and lack of protective gene expression in the cornified envelope.

H, Sugiura; H, Ebise; T, Tazawa; K, Tanaka; Y, Sugiura; M, Uehara; K, Kikuchi; T, Kimura

doi:10.1111/j.1365-2133.2005.06352.x

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Large-scale DNA microarray analysis of atopic skin lesions shows overexpression of an epidermal differentiation gene cluster in the alternative pathway and lack of protective gene expression in the cornified envelope.

Shared by NobleBlocks on Jan 1, 2005 • 12:00 AM UTC

Authors:

Sugiura H

Ebise H

Tazawa T

Abstract

<h4>Background</h4>Atopic dermatitis (AD)-specific genes have not yet been clarified. Objectives To identify gene expression specific to active atopic skin lesions.<h4>Methods</h4>We analysed 23,000 genes in skin biopsy samples from 17 patients with AD and four normal controls using Affymetrix oligo...

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