SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

Rinaldi-Carmona, Murielle; Barth, Francis; Héaulme, Michel; Shire, David; Calandra, Bernard; Congy, Christian; Martinez, Serge; Maruani, Jeanne; Néliat, Gervais; Caput, Daniel; Ferrara, Pascual; Soubrié, Philippe; Claude Brelière, Jean; Le Fur, Gérard

doi:10.1016/0014-5793(94)00773-x

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SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

Shared by NobleBlocks on Aug 22, 1994 • 12:00 AM UTC

Authors:

Murielle Rinaldi-Carmona

Francis Barth

Michel Héaulme

Abstract

SR141716A is the first selective and orally active antagonist of the brain cannabinoid receptor. This compound displays nanomolar affinity for the central cannabinoid receptor but is not active on the peripheral cannabinoid receptor. In vitro, SR141716A antagonises the inhibitory effects of cannabin...

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