Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2.

Bao, Yonghua; Chen, Zhiguo; Guo, Yongchen; Feng, Yansheng; Li, Zexin; Han, Wenliang; Wang, Jianguo; Zhao, Weixing; Jiao, Yunjuan; Li, Kai; Wang, Qian; Wang, Jiaqi; Zhang, Huijuan; Wang, Liang; Yang, Wancai

doi:10.1371/journal.pone.0105991

Public

Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2.

Shared by NobleBlocks on Jan 1, 2014 • 12:00 AM UTC

Authors:

Yonghua Bao

Zhiguo Chen

Yongchen Guo

Abstract

The aberrant expression of microRNAs (miRNAs) is associated with colorectal carcinogenesis, but the underlying mechanisms are not clear. This study showed that the miRNA-27a (miR-27a) was significantly reduced in colorectal cancer tissues and colorectal cancer cell lines, and that the reduced miR-27...

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