Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve.

B, Costa; AE, Trovato; M, Colleoni; G, Giagnoni; E, Zarini; T, Croci

doi:10.1016/j.pain.2005.03.043

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Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve.

Shared by NobleBlocks on Jul 1, 2005 • 12:00 AM UTC

Authors:

Costa B

Trovato AE

Colleoni M

Abstract

Many reports have shown the efficacy of cannabinoid agonists in chronic pain, whereas no report exists concerning the potential effect of cannabinoid antagonists following prolonged treatment. We tested the effects of repeated administration of the selective cannabinoid receptor type 1 (CB1) antagon...

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