Enhanced 15-lipoxygenase activity and elevated eicosanoid production in kidney tumor microenvironment contribute to the inflammation and immune suppression

Kusmartsev, Sergei

doi:10.4161/onci.1.2.18502

Public

Enhanced 15-lipoxygenase activity and elevated eicosanoid production in kidney tumor microenvironment contribute to the inflammation and immune suppression

Published in OncoImmunology • Feb 8, 2012

Authors:

Sergei Kusmartsev

Abstract

Macrophage infiltration is a hallmark in the majority of solid tumors. Our studies demonstrated that macrophages that infiltrate human renal cells carcinoma (RCC) display markedly enhanced expression and activity of 15-lipoxygenase-2 (15-LOX2). Obtained data suggest that enhanced lipoxygenase activi...

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Open Access

Subject

Inflammation

Immune system

Eicosanoid

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