An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12.

N, Morishima; K, Nakanishi; H, Takenouchi; T, Shibata; Y, Yasuhiko

doi:10.1074/jbc.m204973200

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An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12.

Shared by NobleBlocks on Jul 3, 2002 • 12:00 AM UTC

Authors:

Morishima N

Nakanishi K

Takenouchi H

Abstract

Activation of caspase-12 from procaspase-12 is specifically induced by insult to the endoplasmic reticulum (ER) (Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B. A., and Yuan, J. (2000) Nature 403, 98-103), yet the functional consequences of caspase-12 activation have been unclear. ...

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