Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris.

NH, Oberlies; JP, Burgess; HA, Navarro; RE, Pinos; CR, Fairchild; RW, Peterson; DD, Soejarto; NR, Farnsworth; AD, Kinghorn; MC, Wani; ME, Wall

doi:10.1021/np010459m

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Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris.

Shared by NobleBlocks on Feb 1, 2002 • 12:00 AM UTC

Authors:

Oberlies NH

Burgess JP

Navarro HA

Abstract

Fractionation of a methanol extract of the leaves and twigs of Casearia sylvestris, as directed by activity against KB cell cytotoxicity, led to the isolation of three novel clerodane diterpenoids, casearvestrins A-C (1-3). The structures of 1-3 were deduced from one- and two-dimensional NMR experim...

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