Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions.

AE, Rettie; KR, Korzekwa; KL, Kunze; RF, Lawrence; AC, Eddy; T, Aoyama; HV, Gelboin; FJ, Gonzalez; WF, Trager

doi:10.1021/tx00025a009

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Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions.

Shared by NobleBlocks on Jan 1, 1992 • 12:00 AM UTC

Authors:

Rettie AE

Korzekwa KR

Kunze KL

Abstract

Previous kinetic studies have identified a high-affinity (S)-warfarin 7-hydroxylase present in human liver microsomes which appears to be responsible for the termination of warfarin's biological activity. Inhibition of the formation of (S)-7-hydroxywarfarin, the inactive, major metabolite of racemic...

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