Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.

W Lee, S; P Tsou, A; Chan, H; Thomas, J; Petrie, K; M Eugui, E; C Allison, A

doi:10.1073/pnas.85.4.1204

Public

Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA.

Shared by NobleBlocks on Feb 1, 1988 • 12:00 AM UTC

Authors:

S W Lee

A P Tsou

H Chan

Abstract

Transcription of the interleukin 1 beta (IL-1 beta) gene was studied by mRNA hybridization with a cDNA probe in the human promonocytic cell line U-937. Phorbol ester and lipopolysaccharide increased the steady-state level of IL-1 beta mRNA. Glucocorticoids markedly decreased IL-1 beta mRNA levels by...

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