Structures of native human thymidine phosphorylase and in complex with 5-iodouracil.

E, Mitsiki; AC, Papageorgiou; S, Iyer; N, Thiyagarajan; SH, Prior; D, Sleep; C, Finnis; KR, Acharya

doi:10.1016/j.bbrc.2009.06.104

Public

Structures of native human thymidine phosphorylase and in complex with 5-iodouracil.

Shared by NobleBlocks on Jun 23, 2009 • 12:00 AM UTC

Authors:

Mitsiki E

Papageorgiou AC

Iyer S

Abstract

Thymidine phosphorylase (TP) first identified as platelet derived endothelial cell growth factor (PD-ECGF) plays a key role in nucleoside metabolism. Human TP (hTP) is implicated in angiogenesis and is overexpressed in several solid tumors. Here, we report the crystal structures of recombinant hTP a...

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