Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment.

Age-associated memory impairment (AAMI) occurs in many mammalian species, including humans. In contrast to Alzheimer's disease (AD), in which circuit disruption occurs through neuron death, AAMI is due to circuit and synapse disruption in the absence of significant neuron loss and thus may be more a... View More