Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).

M, Iwai; H, Suzuki; I, Ieiri; K, Otsubo; Y, Sugiyama

doi:10.1097/00008571-200411000-00006

Public

Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).

Shared by NobleBlocks on Nov 1, 2004 • 12:00 AM UTC

Authors:

Iwai M

Suzuki H

Ieiri I

Abstract

<h4>Objective</h4>Two kinds of single nucleotide polymorphism (SNP; Asn130Asp and Val174Ala) are frequently observed in the liver specific transporter, organic anion transporting polypeptide 1B1 (OATP1B1/OATP-C) gene. Although these two SNPs occur independently in European-Americans, Val174Ala is mo...

Discussions