Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives.

SR, Chamberlain; L, Menzies; A, Hampshire; J, Suckling; NA, Fineberg; Campo N, del; M, Aitken; K, Craig; AM, Owen; ET, Bullmore; TW, Robbins; BJ, Sahakian

doi:10.1126/science.1154433

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Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives.

Shared by NobleBlocks on Jul 1, 2008 • 12:00 AM UTC

Authors:

Chamberlain SR

Menzies L

Hampshire A

Abstract

Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to neurobiological models of OCD is the orbitofrontal cortex, a neural region that facilitates behavioral flexibility after negative...

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