H2S signals through protein S-sulfhydration.

K Mustafa, Asif; M Gadalla, Moataz; Sen, Nilkantha; Kim, Seyun; Mu, Weitong; K Gazi, Sadia; K Barrow, Roxanne; Yang, Guangdong; Wang, Rui; H Snyder, Solomon

doi:10.1126/scisignal.2000464

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H2S signals through protein S-sulfhydration.

Shared by NobleBlocks on Nov 10, 2009 • 12:00 AM UTC

Authors:

Asif K Mustafa

Moataz M Gadalla

Nilkantha Sen

Abstract

Hydrogen sulfide (H2S), a messenger molecule generated by cystathionine gamma-lyase, acts as a physiologic vasorelaxant. Mechanisms whereby H2S signals have been elusive. We now show that H2S physiologically modifies cysteines in a large number of proteins by S-sulfhydration. About 10 to 25% of many...

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