HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing

Rüschoff, Josef; Dietel, Manfred; Baretton, Gustavo; Arbogast, Susanne; Walch, Axel; Monges, Geneviéve; Chenard, Marie-Pierre; Penault-Llorca, Frédérique; Nagelmeier, Iris; Schlake, Werner; Höfler, H.; H. Kreipe, H.

doi:10.1007/s00428-010-0952-2

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HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing

Shared by NobleBlocks on Jul 28, 2010 • 12:00 AM UTC

Authors:

J. Rüschoff

M. Dietel

G. Baretton

Abstract

Trastuzumab-based therapy has been shown to confer overall survival benefit in HER2-positive patients with advanced gastric cancer in a large multicentric trial (ToGA study). Subgroup analysis identified adenocarcinomas of the stomach and gastroesophageal (GE) junction with overexpression of HER2 ac...

Subject

Medicine

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