MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors.

M, Kato; J, Zhang; M, Wang; L, Lanting; H, Yuan; JJ, Rossi; R, Natarajan

doi:10.1073/pnas.0611192104

Public

MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors.

Shared by NobleBlocks on Feb 20, 2007 • 12:00 AM UTC

Authors:

Kato M

Zhang J

Wang M

Abstract

Key features of diabetic nephropathy (DN) include the accumulation of extracellular matrix proteins such as collagen 1-alpha 1 and -2 (Col1a1 and -2). Transforming growth factor beta1 (TGF-beta), a key regulator of these extracellular matrix genes, is increased in mesangial cells (MC) in DN. By micr...

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