Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease

Shimura, Hideki; G. Schlossmacher, Michael; Hattori, Nobutaka; P. Frosch, Matthew; Trockenbacher, Alexander; Schneider, Rainer; Mizuno, Yoshikuni; S. Kosik, Kenneth; J. Selkoe, Dennis

doi:10.1126/science.1060627

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Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease

Shared by NobleBlocks on Jul 13, 2001 • 12:00 AM UTC

Authors:

Hideki Shimura

Michael G. Schlossmacher

Nobutaka Hattori

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing α-synuclein and ubiquitin. Rare inherited forms of PD are caused by autosomal dominant mutations in α-synuclein or by autosomal recessive...

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