Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel.

DS, Small; NA, Farid; CD, Payne; GJ, Weerakkody; YG, Li; JT, Brandt; DE, Salazar; KJ, Winters

doi:10.1177/0091270008315310

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Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel.

Shared by NobleBlocks on Feb 26, 2008 • 12:00 AM UTC

Authors:

Small DS

Farid NA

Payne CD

Abstract

Prasugrel and clopidogrel, thienopyridine prodrugs, are each metabolized to an active metabolite that inhibits the platelet P2Y(12) ADP receptor. In this open-label, 4-period crossover study, the effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasug...

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