A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Zhang, Weiqi; Li, Jingyi; Suzuki, Keiichiro; Qu, Jing; Wang, Ping; Zhou, Junzhi; Liu, Xiaomeng; Ren, Ruotong; Xu, Xiuling; Ocampo, Alejandro; Yuan, Tingting; Yang, Jiping; Li, Ying; Shi, Liang; Guan, Dee; Pan, Huize; Duan, Shunlei; Ding, Zhichao; Li, Mo; Yi, Fei; Bai, Ruijun; Wang, Yayu; Chen, Chang; Yang, Fuquan; Li, Xiaoyu; Wang, Zimei; Aizawa, Emi; Goebl, April; Devi Soligalla, Rupa; Reddy, Pradeep; Rodriguez Esteban, Concepcion; Tang, Fuchou; Liu, Guang-Hui; Carlos Izpisua Belmonte, Juan

doi:10.1126/science.aaa1356

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A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Shared by NobleBlocks on Jun 5, 2015 • 12:00 AM UTC

Authors:

Weiqi Zhang

Jingyi Li

Keiichiro Suzuki

Abstract

Heterochromatin in aging stem cells Analysis of human aging syndromes, such as Werner syndrome (WS), may lead to greater understanding of both premature and normal aging. Zhang et al. generated isogenic WS-specific human embryonic stem cell lines (see the Perspective by Brunauer and Kennedy). WS-mes...

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