A high-resolution structure of the pre-microRNA nuclear export machinery.

C, Okada; E, Yamashita; SJ, Lee; S, Shibata; J, Katahira; A, Nakagawa; Y, Yoneda; T, Tsukihara

doi:10.1126/science.1178705

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A high-resolution structure of the pre-microRNA nuclear export machinery.

Shared by NobleBlocks on Nov 1, 2009 • 12:00 AM UTC

Authors:

Okada C

Yamashita E

Lee SJ

Abstract

Nuclear export of microRNAs (miRNAs) by exportin-5 (Exp-5) is an essential step in miRNA biogenesis. Here, we present the 2.9 angstrom structure of the pre-miRNA nuclear export machinery formed by pre-miRNA complexed with Exp-5 and a guanine triphosphate (GTP)-bound form of the small nuclear guanine...

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