Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.

DK, Sanghera; L, Ortega; S, Han; J, Singh; SK, Ralhan; GS, Wander; NK, Mehra; JJ, Mulvihill; RE, Ferrell; SK, Nath; MI, Kamboh

doi:10.1186/1471-2350-9-59

Public

Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.

Shared by NobleBlocks on Jul 3, 2008 • 12:00 AM UTC

Authors:

Sanghera DK

Ortega L

Han S

Abstract

<h4>Background</h4>Recent genome-wide association (GWA) studies have identified several unsuspected genes associated with type 2 diabetes (T2D) with previously unknown functions. In this investigation, we have examined the role of 9 most significant SNPs reported in GWA studies: [peroxisome prolifer...

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