The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1.

Y, Xiang; L, Ma; W, Wu; W, Liu; Y, Li; X, Zhu; Q, Wang; J, Ma; M, Cao; Q, Wang; X, Yao; L, Yang; A, Wubuli; C, Merle; P, Milligan; Y, Mao; J, Gu; X, Xin

doi:10.1371/journal.pone.0085905

Public

The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1.

Shared by NobleBlocks on Jan 23, 2014 • 12:00 AM UTC

Authors:

Xiang Y

Ma L

Wu W

Abstract

<h4>Background and objective</h4>Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1, GSTM1and GSTT1, that code for drug-metabol...

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