Genetic loci associated with delayed clearance of <i>Plasmodium falciparum</i> following artemisinin treatment in Southeast Asia

Takala‐Harrison, Shannon; G. Clark, Taane; G. Jacob, Christopher; P. Cummings, Michael; Miotto, Olivo; M. Dondorp, Arjen; M. Fukuda, Mark; Nosten, François; Noedl, Harald; Imwong, Mallika; Bethell, Delia; Se, Youry; Lon, Chanthap; D. Tyner, Stuart; Saunders, David; Socheat, Duong; Ariey, Frédéric; Pyae Phyo, Aung; Starzengrüber, Peter; Fuehrer, Hans‐Peter; Swoboda, Paul; Stepniewska, Kasia; A. Flegg, Jennifer; Arze, Cesar; C. Cerqueira, Gustavo; C. Silva, Joana; Ricklefs, Stacy; F. Porcella, Stephen; M. Stephens, Robert; Adams, Matthew; J. Kenefic, Leo; Campino, Susana; Auburn, Sarah; MacInnis, Bronwyn; Kwiatkowski, Dominic; Su, Xin‐zhuan; J. White, Nicholas; Ringwald, Pascal; V. Plowe, Christopher

doi:10.1073/pnas.1211205110

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Genetic loci associated with delayed clearance of <i>Plasmodium falciparum</i> following artemisinin treatment in Southeast Asia

Shared by NobleBlocks on Dec 17, 2012 • 12:00 AM UTC

Authors:

Shannon Takala‐Harrison

Taane G. Clark

Christopher G. Jacob

Abstract

The recent emergence of artemisinin-resistant Plasmodium falciparum malaria in western Cambodia could threaten prospects for malaria elimination. Identification of the genetic basis of resistance would provide tools for molecular surveillance, aiding efforts to contain resistance. Clinical trials of...

Subject

Artemisinin

Biology

Single-nucleotide polymorphism

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