Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell

Osawa, Masatake; Hanada, Ken-ichi; Hamada, Hirofumi; Nakauchi, Hiromitsu

doi:10.1126/science.273.5272.242

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Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell

Shared by NobleBlocks on Jul 12, 1996 • 12:00 AM UTC

Authors:

Masatake Osawa

Ken-ichi Hanada

Hirofumi Hamada

Abstract

Hematopoietic stem cells (HSCs) supply all blood cells throughout life by making use of their self-renewal and multilineage differentiation capabilities. A monoclonal antibody raised to the mouse homolog of CD34 (mCD34) was used to purify mouse HSCs to near homogeneity. Unlike in humans, primitive a...

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