Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.

Belema, Makonen; N Nguyen, Van; Bachand, Carol; H Deon, Dan; T Goodrich, Jason; A James, Clint; Lavoie, Rico; D Lopez, Omar; Martel, Alain; L Romine, Jeffrey; H Ruediger, Edward; B Snyder, Lawrence; R St Laurent, Denis; Yang, Fukang; Zhu, Juliang; S Wong, Henry; R Langley, David; P Adams, Stephen; H Cantor, Glenn; Chimalakonda, Anjaneya; Fura, Aberra; M Johnson, Benjamin; O Knipe, Jay; D Parker, Dawn; S Santone, Kenneth; A Fridell, Robert; A Lemm, Julie; R O'Boyle, Donald; J Colonno, Richard; Gao, Min; A Meanwell, Nicholas; G Hamann, Lawrence

doi:10.1021/jm401836p

Public

Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.

Shared by NobleBlocks on Mar 13, 2014 • 12:00 AM UTC

Authors:

Makonen Belema

Van N Nguyen

Carol Bachand

Abstract

The biphenyl derivatives 2 and 3 are prototypes of a novel class of NS5A replication complex inhibitors that demonstrate high inhibitory potency toward a panel of clinically relevant HCV strains encompassing genotypes 1-6. However, these compounds exhibit poor systemic exposure in rat pharmacokineti...

Discussions