Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape.

JB, Katz; AJ, Muller; GC, Prendergast

doi:10.1111/j.1600-065x.2008.00610.x

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Indoleamine 2,3-dioxygenase in T-cell tolerance and tumoral immune escape.

Shared by NobleBlocks on Apr 1, 2008 • 12:00 AM UTC

Authors:

Katz JB

Muller AJ

Prendergast GC

Abstract

Indoleamine 2, 3-dioxygenase (IDO) degrades the essential amino acid tryptophan in mammals, catalyzing the initial and rate-limiting step in the de novo biosynthesis nicotinamide adenine dinucleotide (NAD). Broad evidence implicates IDO and the tryptophan catabolic pathway in generation of immune to...

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