The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.

S, Geisler; KM, Holmström; A, Treis; D, Skujat; SS, Weber; FC, Fiesel; PJ, Kahle; W, Springer

doi:10.4161/auto.6.7.13286

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The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations.

Shared by NobleBlocks on Oct 3, 2010 • 12:00 AM UTC

Authors:

Geisler S

Holmström KM

Treis A

Abstract

Mitochondrial dysfunction is an early sign of many neurodegenerative diseases. Very recently, two Parkinson disease (PD) associated genes, PINK1 and Parkin, were shown to mediate the degradation of damaged mitochondria via selective autophagy (mitophagy). PINK1 kinase activity is needed for prompt a...

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